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The ligand-bound VDR heterodimerizes with the Retinoid X Receptor (RXR), and this complex recruits co-regulatory proteins to Vitamin D Response Elements (VDREs) in target genes ( Figure 2 VDR itself, or PDIA3, triggering intracellular cascades such as MAPK/ERK and PI3K/Akt

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If you do experience back pain while taking semaglutide, there are actionable steps to manage it